Pair Name	All-trans retinoic acid, Midostaurin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BRAF	hsa673
	Down-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CASP7	hsa840
	Up-regulation	Expression	CEBPB	hsa1051
	Up-regulation	Expression	CEBPE	hsa1053
	Up-regulation	Expression	FGR	hsa2268
	Up-regulation	Expression	LYN	KEGG ID N.A.
	Up-regulation	Phosphorylation	MAP2K7	hsa5609
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Phosphorylation	RAF1	hsa5894
	Up-regulation	Expression	SPI1	hsa6688
In Vitro Model	HL-60	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_0002
	U-937	Adult acute monocytic leukemia	Homo sapiens (Human)	CVCL_0007
	HL-60Res	Resistant Adult acute myeloid leukemia	Homo sapiens (Human)	N.A.
In Vivo Model	Mice were injected subcutaneously with 5×10⁶ cells.
Result	Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3